HLA Associations and Clinical Implications in T-Cell Mediated Drug Hypersensitivity Reactions: An Updated Review
T-cell mediated drug hypersensitivity reactions may range from mild rash to severe fatal reactions. Among them, drug reaction with eosinophilia and systemic symptoms (DRESS) or drug-induced hypersensitivity syndrome (DIHS), Stevens-Johnson syndrome/ toxic epidermal necrolysis (SJS/TEN), are some of...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2014/565320 |
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| author | Chi-Yuan Cheng Shih-Chi Su Chi-Hua Chen Wei-Li Chen Shin-Tarng Deng Wen-Hung Chung |
| author_facet | Chi-Yuan Cheng Shih-Chi Su Chi-Hua Chen Wei-Li Chen Shin-Tarng Deng Wen-Hung Chung |
| author_sort | Chi-Yuan Cheng |
| collection | DOAJ |
| description | T-cell mediated drug hypersensitivity reactions may range from mild rash to severe fatal reactions. Among them, drug reaction with eosinophilia and systemic symptoms (DRESS) or drug-induced hypersensitivity syndrome (DIHS), Stevens-Johnson syndrome/ toxic epidermal necrolysis (SJS/TEN), are some of the most life-threatening severe cutaneous adverse reactions (SCARs). Recent advances in pharmacogenetic studies show strong genetic associations between human leukocyte antigen (HLA) alleles and susceptibility to drug hypersensitivity. This review summarizes the literature on recent progresses in pharmacogenetic studies and clinical application of pharmacogenetic screening based on associations between SCARs and specific HLA alleles to avoid serious conditions associated with drug hypersensitivity. |
| format | Article |
| id | doaj-art-fccfb6d3d9a64b51a9090a2c99ccae54 |
| institution | OA Journals |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-fccfb6d3d9a64b51a9090a2c99ccae542025-08-20T02:22:40ZengWileyJournal of Immunology Research2314-88612314-71562014-01-01201410.1155/2014/565320565320HLA Associations and Clinical Implications in T-Cell Mediated Drug Hypersensitivity Reactions: An Updated ReviewChi-Yuan Cheng0Shih-Chi Su1Chi-Hua Chen2Wei-Li Chen3Shin-Tarng Deng4Wen-Hung Chung5Department of Pharmacy Administration, Chang Gung Memorial Hospital, Linkou 33305, TaiwanDepartment of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospitals, Linkou 33305, TaiwanDepartment of Pharmacy Administration, Chang Gung Memorial Hospital, Linkou 33305, TaiwanDepartment of Pharmacy Administration, Chang Gung Memorial Hospital, Linkou 33305, TaiwanDepartment of Pharmacy Administration, Chang Gung Memorial Hospital, Linkou 33305, TaiwanDepartment of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospitals, Linkou 33305, TaiwanT-cell mediated drug hypersensitivity reactions may range from mild rash to severe fatal reactions. Among them, drug reaction with eosinophilia and systemic symptoms (DRESS) or drug-induced hypersensitivity syndrome (DIHS), Stevens-Johnson syndrome/ toxic epidermal necrolysis (SJS/TEN), are some of the most life-threatening severe cutaneous adverse reactions (SCARs). Recent advances in pharmacogenetic studies show strong genetic associations between human leukocyte antigen (HLA) alleles and susceptibility to drug hypersensitivity. This review summarizes the literature on recent progresses in pharmacogenetic studies and clinical application of pharmacogenetic screening based on associations between SCARs and specific HLA alleles to avoid serious conditions associated with drug hypersensitivity.http://dx.doi.org/10.1155/2014/565320 |
| spellingShingle | Chi-Yuan Cheng Shih-Chi Su Chi-Hua Chen Wei-Li Chen Shin-Tarng Deng Wen-Hung Chung HLA Associations and Clinical Implications in T-Cell Mediated Drug Hypersensitivity Reactions: An Updated Review Journal of Immunology Research |
| title | HLA Associations and Clinical Implications in T-Cell Mediated Drug Hypersensitivity Reactions: An Updated Review |
| title_full | HLA Associations and Clinical Implications in T-Cell Mediated Drug Hypersensitivity Reactions: An Updated Review |
| title_fullStr | HLA Associations and Clinical Implications in T-Cell Mediated Drug Hypersensitivity Reactions: An Updated Review |
| title_full_unstemmed | HLA Associations and Clinical Implications in T-Cell Mediated Drug Hypersensitivity Reactions: An Updated Review |
| title_short | HLA Associations and Clinical Implications in T-Cell Mediated Drug Hypersensitivity Reactions: An Updated Review |
| title_sort | hla associations and clinical implications in t cell mediated drug hypersensitivity reactions an updated review |
| url | http://dx.doi.org/10.1155/2014/565320 |
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