Acute systemic macrophage depletion in osteoarthritic mice alleviates pain-related behaviors and does not affect joint damage

Acute systemic macrophage depletion in osteoarthritic mice alleviates pain-related behaviors and does not affect joint damage

Abstract Background Osteoarthritis (OA) is a painful degenerative joint disease and a leading source of years lived with disability globally due to inadequate treatment options. Neuroimmune interactions reportedly contribute to OA pain pathogenesis. Notably, in rodents, macrophages in the DRG are as...

Full description

Saved in:
Bibliographic Details
Main Authors: Terese Geraghty, Shingo Ishihara, Alia M. Obeidat, Natalie S. Adamczyk, Rahel S. Hunter, Jun Li, Lai Wang, Hoomin Lee, Frank C. Ko, Anne-Marie Malfait, Rachel E. Miller
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Arthritis Research & Therapy
Subjects:
Osteoarthritis
Pain
Neuroimmune
Macrophages
Dorsal root ganglia
Sensitization
Online Access:https://doi.org/10.1186/s13075-024-03457-9
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s13075-024-03457-9

Similar Items