Impact of aging on gene expression in human oocytes: a comparative analysis of young and older patients

Impact of aging on gene expression in human oocytes: a comparative analysis of young and older patients

Abstract Background Aging affects gene expression in pathways essential for energy metabolism, DNA repair, cell cycle regulation, and antioxidant defenses, directly affecting oocyte quality and viability. Single-cell RNA deep sequencing studies of aged versus young human MII oocytes revealed many di...

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Bibliographic Details
Main Authors: Raoul Orvieto, Omri Nayshool, Louisa Cohen, Yuval Yung, Adva Aizer, Efrat Glick Saar, Dan Dominissini
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Reproductive Biology and Endocrinology
Subjects:
Human oocytes
Ageing
RNA sequencing
GV oocyte
IVF
Online Access:https://doi.org/10.1186/s12958-025-01449-1
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https://doi.org/10.1186/s12958-025-01449-1

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