Brain targeted lipid nanoparticles with Hv1 inhibitors alleviate neuroinflammation post-ischemic stroke

Brain targeted lipid nanoparticles with Hv1 inhibitors alleviate neuroinflammation post-ischemic stroke

Abstract Background Ischemic stroke (IS) represents a significant global health burden. Current therapeutic options face problems such as window narrowing and reperfusion injury risk. Moreover, with increasing aging and risk factors, novel treatment strategies are urgently needed. NADPH oxidase (NOX...

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Main Authors: Zeyu Yang, Lei Jin, Longxiang Li, Yu Wu, Wenchao Liu, Xin Feng, Liyan Li, Fa Jin, Yiming Bi, Ran Li, Shenquan Guo, Yanan Wang, Boyang Wei, Yanchao Liu, Xifeng Li, Chuanzhi Duan
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Nanobiotechnology
Subjects:
Ischemic stroke
Brain-targeted LNP
Microglial
Voltage-gated proton channel Hv1
Neuroinflammation
Online Access:https://doi.org/10.1186/s12951-025-03540-6
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https://doi.org/10.1186/s12951-025-03540-6

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