Immunostimulatory effects mechanism of polysaccharide extracted from Acanthopanax senticosus on RAW 264.7 cells through activating the TLR/MAPK/NF-κB signaling pathway

Immunostimulatory effects mechanism of polysaccharide extracted from Acanthopanax senticosus on RAW 264.7 cells through activating the TLR/MAPK/NF-κB signaling pathway

Abstract Acanthopanax senticosus is a unique wild resource in Northeast China. Its main active ingredient is a polysaccharide, which has a prominent immunomodulatory effect. In this study, the purified polysaccharide component of Acanthopanax senticosus leaves(ASPS-A1) with strong immunomodulatory a...

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Bibliographic Details
Main Authors: Yufan Wang, Lei Wang, Hanwen Zhang, Peirou Ren, Xiaowen Cheng, Fandi Hong, Jiaxin Liu, Ruining Zhang, Jun Zhao, Dongxia Gou
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Acanthopanax senticosus polysaccharide
Structure characterization
RAW 264.7 cells
RNA-seq
Signaling pathway
Online Access:https://doi.org/10.1038/s41598-025-97423-3
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https://doi.org/10.1038/s41598-025-97423-3

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