Cancer Vulnerabilities Through Targeting the ATR/Chk1 and ATM/Chk2 Axes in the Context of DNA Damage

Cancer Vulnerabilities Through Targeting the ATR/Chk1 and ATM/Chk2 Axes in the Context of DNA Damage

Eliciting DNA damage in tumor cells continues to be one of the most successful strategies against cancer. This is the case for classical chemotherapy drugs and radiotherapy. In the modern era of personalized medicine, this strategy tries to identify specific vulnerabilities found in each patient’s t...

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Bibliographic Details
Main Authors: Anell Fernandez, Maider Artola, Sergio Leon, Nerea Otegui, Aroa Jimeno, Diego Serrano, Alfonso Calvo
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Cells
Subjects:
ATR
Chk1
ATM
Chk2
DNA damage
synthetic lethality
Online Access:https://www.mdpi.com/2073-4409/14/10/748
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