Assessing Cardiomyocyte DNA Damage Using Cardiovascular Magnetic Resonance T1 Mapping

Assessing Cardiomyocyte DNA Damage Using Cardiovascular Magnetic Resonance T1 Mapping

Background: DNA damage in cardiomyocytes is a key pathological pathway in heart failure progression. It is a reversible process that precedes apoptosis and fibrosis. However, the utility of cardiovascular magnetic resonance T1 mapping for assessing DNA damage is uncertain. Objectives: This study aim...

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Main Authors: Mizuki Ichikawa, MD, Shiro Nakamori, MD, Masaki Ishida, MD, Ryuji Okamoto, MD, Rie Ito, BSc, Agr, Junko Ishiura, MD, Masaki Ishiyama, MD, Taku Omori, MD, Keishi Moriwaki, MD, Emiyo Sugiura, MD, Naoki Fujimoto, MD, Tairo Kurita, MD, Yasutaka Ichikawa, MD, Kakuya Kitagawa, MD, Kyoko Imanaka-Yoshida, MD, Hajime Sakuma, MD, Kaoru Dohi, MD
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:JACC: Advances
Subjects:
cardiovascular magnetic resonance
dilated cardiomyopathy
DNA damage
fibrosis
myocardial tissue recovery
native T1
Online Access:http://www.sciencedirect.com/science/article/pii/S2772963X25004375
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