Cocultured amniotic stem cells and cardiomyocytes in a 3-D acellular heart patch reduce the infarct size and left ventricle remodeling: promote angiogenesis in a porcine acute myocardial infarction model

Cocultured amniotic stem cells and cardiomyocytes in a 3-D acellular heart patch reduce the infarct size and left ventricle remodeling: promote angiogenesis in a porcine acute myocardial infarction model

Abstract Background Acute myocardial infarction (AMI) induces significant myocardial damage, ultimately leading to heart failure as the surrounding healthy myocardial tissue undergoes progressive deterioration due to excessive mechanical stress. Methods This study aimed to investigate myocardial reg...

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Bibliographic Details
Main Authors: Muhammad Arza Putra, Normalina Sandora, Tri Wisesa Soetisna, Tyas Rahmah Kusuma, Nur Amalina Fitria, Benati Karimah, Deni Noviana, Gunanti, Pribadi Wiranda Busro, Supomo, Idrus Alwi
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Cardiothoracic Surgery
Subjects:
Myocardial infarction
Animal models
Cardiomyogenesis
Amnion epithelial stem cells
Cardiomyocytes
Amnion bilayer 3-D scaffold
Online Access:https://doi.org/10.1186/s13019-025-03453-3
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https://doi.org/10.1186/s13019-025-03453-3

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