Loss of RASGRP1 in humans impairs T‐cell expansion leading to Epstein‐Barr virus susceptibility

Loss of RASGRP1 in humans impairs T‐cell expansion leading to Epstein‐Barr virus susceptibility

Abstract Inherited CTPS1, CD27, and CD70 deficiencies in humans have revealed key factors of T‐lymphocyte expansion, a critical prerequisite for an efficient immunity to Epstein–Barr virus (EBV) infection. RASGRP1 is a T‐lymphocyte‐specific nucleotide exchange factor known to activate the pathway of...

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Bibliographic Details
Main Authors: Sarah Winter, Emmanuel Martin, David Boutboul, Christelle Lenoir, Sabah Boudjemaa, Arnaud Petit, Capucine Picard, Alain Fischer, Guy Leverger, Sylvain Latour
Format: Article
Language:English
Published: Springer Nature 2018-01-01
Series:EMBO Molecular Medicine
Subjects:
Hodgkin lymphoma
immunodeficiency
lymphocyte
susceptibility to Epstein–Barr virus
T‐cell proliferation
Online Access:https://doi.org/10.15252/emmm.201708292
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https://doi.org/10.15252/emmm.201708292

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