Bioengineering the Human Intestinal Mucosa and the Importance of Stromal Support for Pharmacological Evaluation In Vitro

Bioengineering the Human Intestinal Mucosa and the Importance of Stromal Support for Pharmacological Evaluation In Vitro

Drug discovery is associated with high levels of compound elimination in all stages of development. The current practices for the pharmacokinetic testing of intestinal absorption combine Transwell<sup>®</sup> inserts with the Caco-2 cell line and are associated with a wide range of limit...

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Bibliographic Details
Main Authors: Matthew Freer, Jim Cooper, Kirsty Goncalves, Stefan Przyborski
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Cells
Subjects:
intestine
tissue engineering
drug discovery
fibroblast
keratinocyte growth factor
Caco-2
Online Access:https://www.mdpi.com/2073-4409/13/22/1859
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