Identification of Food-Derived Electrophilic Chalcones as Nrf2 Activators Using Comprehensive Virtual Screening Techniques

Identification of Food-Derived Electrophilic Chalcones as Nrf2 Activators Using Comprehensive Virtual Screening Techniques

Electrophilic compounds are bioactive components commonly found in foods that are capable of covalently modifying nucleophilic sites on biologically functional macromolecules. These compounds may elicit positive bioactivity or negative biotoxicity, posing significant challenges in terms of time and...

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Bibliographic Details
Main Authors: Bingyu Bai, Piaohan Tu, Jiayi Weng, Yan Zhang, Quan Lin, Mitchell N. Muskat, Jie Wang, Xue Tang, Xiangrong Cheng
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Antioxidants
Subjects:
electrophilic compounds
machine learning
molecular docking
Nrf2 activators
chalcones
Online Access:https://www.mdpi.com/2076-3921/14/5/546
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