Creation of Genetically Modified Adipocytes for Tissue Engineering: Creatine Kinase B Overexpression Leads to Stimulated Glucose Uptake and Mitochondrial Potential Growth, but Lowered Lipid Synthesis

Creation of Genetically Modified Adipocytes for Tissue Engineering: Creatine Kinase B Overexpression Leads to Stimulated Glucose Uptake and Mitochondrial Potential Growth, but Lowered Lipid Synthesis

Background: The global burden of obesity and type 2 diabetes mellitus is a significant contributor to mortality and disability in the modern world. In this regard, the modification of adipocyte metabolism has been identified as a promising approach to develop new genetic and cellular engineering the...

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Main Authors: Svetlana Michurina, Irina Beloglazova, Margarita Agareva, Natalia Alekseeva, Yelena Parfyonova, Iurii Stafeev
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Life
Subjects:
adipocytes
thermogenesis
creatine kinase B
glucose metabolism
lipid metabolism
Online Access:https://www.mdpi.com/2075-1729/15/5/753
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