Development and characterization of a double-fluorescent HIV-1 reporter cellular model to tackle the Rev-dependent export pathway

Development and characterization of a double-fluorescent HIV-1 reporter cellular model to tackle the Rev-dependent export pathway

ABSTRACT The Rev-dependent nuclear export of unspliced and singly-spliced transcripts of human immunodeficiency virus type 1 (HIV-1) constitutes a critical yet poorly characterized post-transcriptional event essential for effective viral replication. In this study, we engineered a dual-fluorescent H...

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Bibliographic Details
Main Authors: Jakub Wadas, Haider Ali, Aleksandra Osiecka, Agnieszka Dorman, Krzysztof Pyrc, Anna Kula-Pacurar
Format: Article
Language:English
Published: American Society for Microbiology 2025-03-01
Series:Microbiology Spectrum
Subjects:
HIV-1
Rev protein
Rev cofactors
HIV-1 RNA processing
Rev-dependent export
reporter system
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01903-24
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https://journals.asm.org/doi/10.1128/spectrum.01903-24

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