Persistent epigenetic memory of SARS-CoV-2 mRNA vaccination in monocyte-derived macrophages

Persistent epigenetic memory of SARS-CoV-2 mRNA vaccination in monocyte-derived macrophages

Abstract Immune memory plays a critical role in the development of durable antimicrobial immune responses. How precisely mRNA vaccines train innate immune cells to shape protective host defense mechanisms remains unknown. Here we show that SARS-CoV-2 mRNA vaccination significantly establishes histon...

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Main Authors: Alexander Simonis, Sebastian J Theobald, Anna E Koch, Ram Mummadavarapu, Julie M Mudler, Andromachi Pouikli, Ulrike Göbel, Richard Acton, Sandra Winter, Alexandra Albus, Dmitriy Holzmann, Marie-Christine Albert, Michael Hallek, Henning Walczak, Thomas Ulas, Manuel Koch, Peter Tessarz, Robert Hänsel-Hertsch, Jan Rybniker
Format: Article
Language:English
Published: Springer Nature 2025-03-01
Series:Molecular Systems Biology
Subjects:
Epigenetic Memory
Trained Innate Immunity
SARS-Cov-2 mRNA Vaccination
H3K27ac
G-quadruplex
Online Access:https://doi.org/10.1038/s44320-025-00093-6
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https://doi.org/10.1038/s44320-025-00093-6

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