Demethylzeylasteral suppresses the expression of MESP1 by reducing H3K18la level to inhibit the malignant behaviors of pancreatic cancer
Abstract Glycolysis is a hallmark metabolic pathway in pancreatic cancer (PC). As the end product of glycolysis, lactic acid accumulates significantly in PC. Lactic acid serves as a primary substrate for histone lactylation, leading to an upregulation of histone lactylation levels, which likely cont...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2025-07-01
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| Series: | Cell Death Discovery |
| Online Access: | https://doi.org/10.1038/s41420-025-02603-9 |
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