Age-related cerebral amyloid angiopathy accumulation in the APPSw mouse model is associated with perivascular inflammation and brain-wide vascular and inflammatory gene and protein changes

Age-related cerebral amyloid angiopathy accumulation in the APPSw mouse model is associated with perivascular inflammation and brain-wide vascular and inflammatory gene and protein changes

Cerebral amyloid angiopathy (CAA) is an extremely common pathology of Alzheimer's disease (AD) included under vascular contributions to cognitive impairment and dementia (VCID). CAA has been reported in 78–98 % of AD cases and has clinical significance when considering side effects that arise w...

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Bibliographic Details
Main Authors: Katelynn E. Krick, Erica M. Weekman, Sherika N. Johnson, Tiffany L. Sudduth, Colin B. Rogers, Emma J. Nicolayson, Maureen T. Kleinhenz, Donna M. Wilcock
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Neurobiology of Disease
Subjects:
Cerebral amyloid angiopathy (CAA)
Cerebrovasculature
Alzheimer's disease (AD)
Vascular contributions to cognitive impairment and dementia (VCID)
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996125002293
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