FoxO3 controls cardiomyocyte proliferation and heart regeneration by regulating Sfrp2 expression in postnatal mice

FoxO3 controls cardiomyocyte proliferation and heart regeneration by regulating Sfrp2 expression in postnatal mice

Abstract The Forkhead box O3 (FoxO3) transcription factor is crucial to controlling heart growth in adulthood, but its exact role in cardiac repair and regeneration in postnatal mice remains unclear. Here, we show that FoxO3 deficiency promotes cardiomyocyte proliferation in postnatal mice and impro...

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Main Authors: Jing-Bo Xia, Kun Liu, Xiao-Lin Lin, Hong-Ji Li, Jin-Hua Lin, Li Li, Chi-Qian Liang, Yan Cao, Na Wen, Zhao-Fu Liao, Hui Zhao, Kyu-Sang Park, Guo-Hua Song, Ze-Bing Ye, Dong-Qing Cai, Zhen-Yu Ju, Xu-Feng Qi
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57962-9
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https://doi.org/10.1038/s41467-025-57962-9

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