Knockdown and overexpression of basolateral amygdala SIRT1 via AAV bidirectionally alter morphine-induced conditioned place preference extinction in mice

Knockdown and overexpression of basolateral amygdala SIRT1 via AAV bidirectionally alter morphine-induced conditioned place preference extinction in mice

IntroductionThis study investigates the role of SIRT1 in basolateral amygdala (BLA) glutamatergic neurons in morphine-induced conditioned place preference (CPP).MethodsVia SIRT1 knockdown/overexpression in bilateral BLA of morphine-induced CPP mice. Outcomes measured by behavioral tests, WB, and tra...

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Bibliographic Details
Main Authors: Guo Hao, Yao Mingchen, Zheng Yalin, Qu Yaqi, Yang Tingwu, Xing Xinru, Li Kaixuan, Dong Yani, Liu Dongsen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Cellular Neuroscience
Subjects:
SIRT1
basolateral amygdala
morphine
conditioned place preference
extinction
reinstatement
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2025.1604914/full
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https://www.frontiersin.org/articles/10.3389/fncel.2025.1604914/full

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