“Microbial and immune modulation by 2’-fucosyllactose supplementation during gestation: a strategy to prevent food allergies”
Food allergies are linked to dysfunction in intestinal microbiota, the immune system and the intestinal epithelial barrier, leading to immune tolerance failure at birth. We hypothesized that a diet enriched with a Human Milk Oligosaccharide (HMO), the 2’-fucosyllactose (2’-FL), during pregnancy woul...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Gut Microbes |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2025.2523813 |
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| author | Carole Brosseau Anaïs Rousseaux Marine Le Romancer Marie Hélène Ropers Virginie Lollier Marion De Carvalho Sébastien Barbarot Marie Bodinier |
| author_facet | Carole Brosseau Anaïs Rousseaux Marine Le Romancer Marie Hélène Ropers Virginie Lollier Marion De Carvalho Sébastien Barbarot Marie Bodinier |
| author_sort | Carole Brosseau |
| collection | DOAJ |
| description | Food allergies are linked to dysfunction in intestinal microbiota, the immune system and the intestinal epithelial barrier, leading to immune tolerance failure at birth. We hypothesized that a diet enriched with a Human Milk Oligosaccharide (HMO), the 2’-fucosyllactose (2’-FL), during pregnancy would enhance the establishment of these systems and protect the child against food allergy. We previously demonstrated that in our mouse model, 2’-FL protected offspring from food allergy, abrogating allergic symptoms and reducing associated biomarkers. This study investigated microbial, immune, metabolic and gut physiology in mothers, fetuses and offspring to understand the mechanisms behind this protection. Gestational 2’-FL supplementation significantly modified maternal gut microbiota and induced regulatory B cells, which were also seen in fetuses. Additionally, pups from 2’-FL supplemented mothers exhibited distinct microbiota, a strengthened intestinal barrier, and more regulatory B cells compared to control pups. Our results demonstrate that 2’-FL supplementation during gestation induces lasting beneficial changes, protecting offspring from food allergies. |
| format | Article |
| id | doaj-art-fb86de59cae24fdeab5c25702a48967d |
| institution | Kabale University |
| issn | 1949-0976 1949-0984 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj-art-fb86de59cae24fdeab5c25702a48967d2025-08-20T03:32:45ZengTaylor & Francis GroupGut Microbes1949-09761949-09842025-12-0117110.1080/19490976.2025.2523813“Microbial and immune modulation by 2’-fucosyllactose supplementation during gestation: a strategy to prevent food allergies”Carole Brosseau0Anaïs Rousseaux1Marine Le Romancer2Marie Hélène Ropers3Virginie Lollier4Marion De Carvalho5Sébastien Barbarot6Marie Bodinier7INRAE, UR BIA, Nantes, FranceINRAE, UR BIA, Nantes, FranceINRAE, UR BIA, Nantes, FranceINRAE, UR BIA, Nantes, FranceINRAE, UR BIA, Nantes, FranceINRAE, UR BIA, Nantes, FranceDepartment of Dermatology, CHU Nantes, Nantes, FranceINRAE, UR BIA, Nantes, FranceFood allergies are linked to dysfunction in intestinal microbiota, the immune system and the intestinal epithelial barrier, leading to immune tolerance failure at birth. We hypothesized that a diet enriched with a Human Milk Oligosaccharide (HMO), the 2’-fucosyllactose (2’-FL), during pregnancy would enhance the establishment of these systems and protect the child against food allergy. We previously demonstrated that in our mouse model, 2’-FL protected offspring from food allergy, abrogating allergic symptoms and reducing associated biomarkers. This study investigated microbial, immune, metabolic and gut physiology in mothers, fetuses and offspring to understand the mechanisms behind this protection. Gestational 2’-FL supplementation significantly modified maternal gut microbiota and induced regulatory B cells, which were also seen in fetuses. Additionally, pups from 2’-FL supplemented mothers exhibited distinct microbiota, a strengthened intestinal barrier, and more regulatory B cells compared to control pups. Our results demonstrate that 2’-FL supplementation during gestation induces lasting beneficial changes, protecting offspring from food allergies.https://www.tandfonline.com/doi/10.1080/19490976.2025.2523813Gut microbiotametabolitesfeto-maternal tissuesgut barrier. Human milk Oligosaccharidesfood allergyDevelopmental Origins of Health and Disease (DoHAD) |
| spellingShingle | Carole Brosseau Anaïs Rousseaux Marine Le Romancer Marie Hélène Ropers Virginie Lollier Marion De Carvalho Sébastien Barbarot Marie Bodinier “Microbial and immune modulation by 2’-fucosyllactose supplementation during gestation: a strategy to prevent food allergies” Gut Microbes Gut microbiota metabolites feto-maternal tissues gut barrier. Human milk Oligosaccharides food allergy Developmental Origins of Health and Disease (DoHAD) |
| title | “Microbial and immune modulation by 2’-fucosyllactose supplementation during gestation: a strategy to prevent food allergies” |
| title_full | “Microbial and immune modulation by 2’-fucosyllactose supplementation during gestation: a strategy to prevent food allergies” |
| title_fullStr | “Microbial and immune modulation by 2’-fucosyllactose supplementation during gestation: a strategy to prevent food allergies” |
| title_full_unstemmed | “Microbial and immune modulation by 2’-fucosyllactose supplementation during gestation: a strategy to prevent food allergies” |
| title_short | “Microbial and immune modulation by 2’-fucosyllactose supplementation during gestation: a strategy to prevent food allergies” |
| title_sort | microbial and immune modulation by 2 fucosyllactose supplementation during gestation a strategy to prevent food allergies |
| topic | Gut microbiota metabolites feto-maternal tissues gut barrier. Human milk Oligosaccharides food allergy Developmental Origins of Health and Disease (DoHAD) |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2025.2523813 |
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