Piezo1 disrupts blood–brain barrier via CaMKII/Nrf2 in ischemic stroke

Piezo1 disrupts blood–brain barrier via CaMKII/Nrf2 in ischemic stroke

Abstract Ischemic stroke (IS) leads to the disruption of blood–brain barrier (BBB) integrity, resulting in brain edema. In this process, endothelial cells, as a crucial component of the BBB, are subjected to external pressure and tensile stress. Piezo1, a mechanically-sensitive ion channel, may be a...

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Bibliographic Details
Main Authors: Huimin Fu, Yang Yu, Shangyuan Wang, Peixian Xu, Yuting Sun, Jiaqi Li, Xiaoli Ge, Shuming Pan
Format: Article
Language:English
Published: Springer 2025-06-01
Series:Cellular and Molecular Life Sciences
Subjects:
Endothelial dysfunction
Oxidative stress
Neuroinflammation
Mitochondrial dysfunction
Online Access:https://doi.org/10.1007/s00018-025-05804-8
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https://doi.org/10.1007/s00018-025-05804-8

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