Optogenetic restoration of high-sensitivity vision using ChRmine- and ChroME-based channelrhodopsins

Optogenetic restoration of high-sensitivity vision using ChRmine- and ChroME-based channelrhodopsins

Abstract Optogenetic gene therapy is a promising mutation-independent treatment that aims to restore visual perception in patients blinded by retinal diseases that cause photoreceptor degeneration. Still, low sensitivity or slow kinetics of currently utilized optogenetic proteins limit the efficacy...

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Main Authors: Victoria C. Fong, Beatrice M. Le, Antonia Stefanov, Vivian Lee, Seohyun Park, Adithya Sivakumar, Sabrina Spatny, Meike Visel, W. Rowland Taylor, Stephen G. Brohawn, John G. Flannery
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Optogenetics
Retinal disease
Vision restoration
Channelrhodopsin
Gene therapy
Mouse behavior
Online Access:https://doi.org/10.1038/s41598-025-04286-9
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https://doi.org/10.1038/s41598-025-04286-9

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