Phagosomal RNA sensing through TLR8 controls susceptibility to tuberculosis

Phagosomal RNA sensing through TLR8 controls susceptibility to tuberculosis

Summary: Genetic determinants of susceptibility to Mycobacterium tuberculosis (Mtb) remain poorly understood but could provide insights into critical pathways involved in infection, informing host-directed therapies and enabling risk stratification at individual and population levels. Through a geno...

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Main Authors: Charlotte Maserumule, Charlotte Passemar, Olivia S.H. Oh, Kriztina Hegyi, Karen Brown, Aaron Weimann, Adam Dinan, Sonia Davila, Catherine Klapholz, Josephine Bryant, Deepshikha Verma, Jacob Gadwa, Shivankari Krishnananthasivam, Kridakorn Vongtongsalee, Edward Kendall, Andres Trelles, Martin L. Hibberd, Joaquín Sanz, Jorge Bertol, Lucia Vázquez-Iniesta, Kaliappan Andi, S. Siva Kumar, Diane Ordway, Rafael Prados-Rosales, Paul A. MacAry, R. Andres Floto
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Cell Reports
Subjects:
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725004280
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