IDO1 induced macrophage M1 polarization via ER stress-associated GRP78-XBP1 pathway to promote ulcerative colitis progression

IDO1 induced macrophage M1 polarization via ER stress-associated GRP78-XBP1 pathway to promote ulcerative colitis progression

Ulcerative colitis (UC) is a chronic inflammatory bowel disorder distinguished by alternating phases of remission and exacerbation. Restoring immune balance through the modulation of M1 macrophage polarization represents a potentially valuable therapeutic strategy for UC. Indoleamine 2,3-dioxygenase...

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Bibliographic Details
Main Authors: Zijian Gao, Shuai Shao, Zhen Xu, Jiao Nie, Chenglin Li, Chao Du
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Medicine
Subjects:
ulcerative colitis
macrophages
indoleamine 2,3-dioxygenase-1
GRP78
XBP1
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2025.1524952/full
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https://www.frontiersin.org/articles/10.3389/fmed.2025.1524952/full

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