RETRACTED ARTICLE: Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells

RETRACTED ARTICLE: Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells

Abstract Background More than 80% of intestinal neoplasia is associated with the adenomatous polyposis coli (APC) mutation. Doublecortin-like kinase 1 (Dclk1), a kinase protein, is overexpressed in colorectal cancer and specifically marks tumor stem cells (TSCs) that self-renew and increased the tum...

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Bibliographic Details
Main Authors: Parthasarathy Chandrakesan, Jiannan Yao, Dongfeng Qu, Randal May, Nathaniel Weygant, Yang Ge, Naushad Ali, Sripathi M. Sureban, Modhi Gude, Kenneth Vega, Eddie Bannerman-Menson, Lijun Xia, Michael Bronze, Guangyu An, Courtney W. Houchen
Format: Article
Language:English
Published: BMC 2017-02-01
Series:Molecular Cancer
Subjects:
Dclk1
APC mutation
Cancer stem cells
Intestinal epithelial cells
Pro-survival signaling
Self-renewal
Online Access:https://doi.org/10.1186/s12943-017-0594-y
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https://doi.org/10.1186/s12943-017-0594-y

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