Tumor-infiltrating lymphocytes in cancer immunotherapy: from chemotactic recruitment to translational modeling

Tumor-infiltrating lymphocytes in cancer immunotherapy: from chemotactic recruitment to translational modeling

Tumor-infiltrating lymphocytes (TILs) are a diverse population of immune cells that play a central role in tumor immunity and have emerged as critical mediators in cancer immunotherapy. This review explores the phenotypic and functional diversity of TILs—including CD8+ cytotoxic T cells, CD4+ helper...

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Main Authors: Fatjona Pupuleku Kraja, Vladimir B. Jurisic, Altijana Hromić-Jahjefendić, Nafsika Rossopoulou, Theodora Katsila, Katarina Mirjacic Martinovic, Javier De Las Rivas, Carmen Cristina Diaconu, Árpád Szöőr
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
tumor-infiltrating lymphocytes
tumor microenvironment
immunotherapy
adoptive cell transfer
experimental models
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1601773/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1601773/full

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