Adenoviruses Encapsulated in PEGylated DOTAP-Folate Liposomes Are Protected from the Pre-Existing Humoral Immune Response

Adenoviruses Encapsulated in PEGylated DOTAP-Folate Liposomes Are Protected from the Pre-Existing Humoral Immune Response

<b>Background/Objectives</b>: While adenovirus (Ad) therapies have been proven to be effective in local administration, systemic Ad treatments have shown limited success due to pre-existing antibodies in the human blood that neutralize the virus. We developed a liposome coating procedure...

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Bibliographic Details
Main Authors: Abraham T. Phung, Jaimin R. Shah, Tao Dong, Omonigho Aisagbonhi, William C. Trogler, Andrew C. Kummel, Sarah L. Blair
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Pharmaceutics
Subjects:
liposome
adenovirus
PEG
neutralizing antibodies
systemic administration
Online Access:https://www.mdpi.com/1999-4923/17/6/769
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https://www.mdpi.com/1999-4923/17/6/769

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