Multiplexed immune profiling and 3D co-culture assays to assess the individual checkpoint therapy response in head and neck squamous cell carcinoma

Multiplexed immune profiling and 3D co-culture assays to assess the individual checkpoint therapy response in head and neck squamous cell carcinoma

BackgroundImmune checkpoint inhibitors (ICIs) have become an integral part of cancer therapy, but only a minority of patients experience durable responsiveness. Response rates vary greatly and are often unpredictable, highlighting the urgent need for predictive biomarkers to guide treatment decision...

Full description

Saved in:
Bibliographic Details
Main Authors: Verena Schweihofer, Daniela Schulz, Raquel Blazquez, Gero Brockhoff, Tobias Ettl, Mathias Fiedler, Sina Heimer, Juliane Schikora, Richard J. Bauer, Anja Kathrin Wege
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Oncology
Subjects:
head and neck squamous cell carcinoma (HNSCC)
immune checkpoint inhibitors (ICI)
tumor microenvironment (TME)
multiplexed immune profiling
(patient-derived) organotypic slice co-culture
predictive biomarkers
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1622008/full
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2025.1622008/full

Similar Items