Regulatory role of S1P and its receptors in sepsis-induced liver injury

Regulatory role of S1P and its receptors in sepsis-induced liver injury

As an immune and metabolic organ, the liver affects the progression and prognosis of sepsis. Despite the severe adverse effects of sepsis liver injury on the body, treatment options remain limited. Sphingosine-1-phosphate (S1P) is a widely distributed lipid signaling molecule that binds to five sphi...

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Bibliographic Details
Main Authors: Bin Wang, Xiaoyu Wu, Jiangfeng Cheng, Junming Ye, Hongquan Zhu, Xiaofeng Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
S1P
S1PRs
sepsis
immune
bile acid metabolism
liver-intestinal circulation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1489015/full
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