The MHC-I-dependent neoantigen presentation pathway predicts response rate to PD-1/PD-L1 blockade

The MHC-I-dependent neoantigen presentation pathway predicts response rate to PD-1/PD-L1 blockade

Immune checkpoint inhibitors produce durable antitumor effects in various cancers, but not all patients respond. High tumor mutational burden (TMB) is a known predictor of clinical benefit. In this study, we focused on the MHC-I-dependent neoantigen presentation pathway to enhance predictive capabi...

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Bibliographic Details
Main Authors: Yuchen Zhang, Chen Yang, Yanchao Xu, Xiang Jiang, Jiajun Shi, Binghua Li, Decai Yu
Format: Article
Language:English
Published: Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina 2024-11-01
Series:Biomolecules & Biomedicine
Subjects:
checkpoint blockades
immunotherapy
response prediction
MHC-I pathway
tumor mutational burden
TMB
Online Access:https://bjbms.org/ojs/index.php/bjbms/article/view/11069
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