Modulating immune-stem cell crosstalk enables robust bone regeneration via tuning compositions of macroporous scaffolds

Modulating immune-stem cell crosstalk enables robust bone regeneration via tuning compositions of macroporous scaffolds

Abstract Following bone injury, macrophages (Mφ) initiate the immune response by secreting signals that recruit mesenchymal stem cells (MSC) and other niche cells to shape healing. Despite its importance, the potential of enhancing bone regeneration by modulating immune-stem cell crosstalk is largel...

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Main Authors: Ni Su, Heena Saqib, Cassandra Villicana, Sungwon Kim, Thomas H. Ambrosi, Peyton Freeman, Tayne Kim, Xinming Tong, Manish Ayushman, Charles K. F. Chan, Fan Yang
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:npj Regenerative Medicine
Online Access:https://doi.org/10.1038/s41536-025-00421-2
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https://doi.org/10.1038/s41536-025-00421-2

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