p52-ZER6/DAZAP1 axis promotes ferroptosis resistance and colorectal cancer progression via regulating SLC7A11 mRNA stabilization

p52-ZER6/DAZAP1 axis promotes ferroptosis resistance and colorectal cancer progression via regulating SLC7A11 mRNA stabilization

Resistance to ferroptosis, a form of regulated cell death caused by disruptions in iron ion and intracellular redox homeostasis, is closely related to tumorigenesis and tumor drug resistance; therefore, targeting ferroptosis-related pathways has garnered attention as a potential antitumor therapeuti...

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Bibliographic Details
Main Authors: Li Qiu, Wenfang Li, Lei Zhang, Xia Zhang, Hezhao Zhao, Makoto Miyagishi, Shourong Wu, Vivi Kasim
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Tumor cell ferroptosis
mRNA stabilization
RNA binding protein
Zinc-finger protein
ZER6
p52-ZER6
Online Access:http://www.sciencedirect.com/science/article/pii/S221138352500067X
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