Halofuginone Disrupted Collagen Deposition via mTOR‐eIF2α‐ATF4 Axis to Enhance Chemosensitivity in Ovarian Cancer

Halofuginone Disrupted Collagen Deposition via mTOR‐eIF2α‐ATF4 Axis to Enhance Chemosensitivity in Ovarian Cancer

Abstract The interplay between cancer‐associated fibroblasts (CAFs) and extracellular matrix (ECM) mediates progress, metastasis, and therapy resistance. However, strategy of targeting ECM remodeling to enhance chemosensitivity in ovarian cancer remains elusive. Here, a 22‐gene matrisome signature p...

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Bibliographic Details
Main Authors: Wenxin Li, Yenan Wu, Yanan Zhang, Wenyan Gao, Xin Li, Haixia Luo, Mengmeng Lu, Zhihua Liu, Aiping Luo
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Advanced Science
Subjects:
cancer‐associated fibroblasts (CAFs)
COL1A1
extracellular matrix
fibrosis
halofuginone
ovarian cancer
Online Access:https://doi.org/10.1002/advs.202416523
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https://doi.org/10.1002/advs.202416523

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