Activation of the Staphylococcus aureus intramembrane sensing histidine kinase SaeS via intramembrane interaction with the bacterially encoded small protein ScrA

Activation of the Staphylococcus aureus intramembrane sensing histidine kinase SaeS via intramembrane interaction with the bacterially encoded small protein ScrA

ABSTRACT Two-component systems represent a fundamental sense-response mechanism in bacterial cells and often play important roles in critical processes such as quorum sensing, antibiotic tolerance, and virulence. Much has been learned about the role/activity of response regulator proteins, and their...

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Bibliographic Details
Main Authors: Marcus A. Wittekind, Ian R. Monk, Ryan W. Steere, Emily G. Sudnick, Donald Holzschu, Padraig Deighan, Timothy P. Stinear, Ronan K. Carroll
Format: Article
Language:English
Published: American Society for Microbiology 2025-07-01
Series:mBio
Subjects:
two component system
signal transduction
histidine kinase
intramembrane
SaeS
Online Access:https://journals.asm.org/doi/10.1128/mbio.01531-25
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https://journals.asm.org/doi/10.1128/mbio.01531-25

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