Exploiting TCR Repertoire Analysis to Select Therapeutic TCRs for Cancer Immunotherapy

Exploiting TCR Repertoire Analysis to Select Therapeutic TCRs for Cancer Immunotherapy

Over the past decade, numerous innovative immunotherapy strategies have transformed the treatment of cancer and improved the survival of patients unresponsive to conventional chemotherapy and radiation therapy. Immune checkpoint inhibition approaches aim to block negative regulatory pathways that li...

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Bibliographic Details
Main Authors: Ursule M. Demaël, Thunchanok Rirkkrai, Fatma Zehra Okus, Andreas Tiffeau-Mayer, Hans J. Stauss
Format: Article
Language:English
Published: MDPI AG 2025-08-01
Series:Cells
Subjects:
T cell receptor
TCR sequencing
TCR repertoire
tumour infiltrating lymphocytes
meta-clonotype
cancer immunotherapy
Online Access:https://www.mdpi.com/2073-4409/14/15/1223
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https://www.mdpi.com/2073-4409/14/15/1223

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