A Versatile Strategy for Production of Membrane Proteins with Diverse Topologies: Application to Investigation of Bacterial Homologues of Human Divalent Metal Ion and Nucleoside Transporters.

A Versatile Strategy for Production of Membrane Proteins with Diverse Topologies: Application to Investigation of Bacterial Homologues of Human Divalent Metal Ion and Nucleoside Transporters.

Membrane proteins play key roles in many biological processes, from acquisition of nutrients to neurotransmission, and are targets for more than 50% of current therapeutic drugs. However, their investigation is hampered by difficulties in their production and purification on a scale suitable for str...

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Main Authors: Cheng Ma, Zhenyu Hao, Gerard Huysmans, Amelia Lesiuk, Per Bullough, Yingying Wang, Mark Bartlam, Simon E Phillips, James D Young, Adrian Goldman, Stephen A Baldwin, Vincent L G Postis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0143010
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https://doi.org/10.1371/journal.pone.0143010

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