The Immunomodulatory Effects of Apigenin and Quercetin on Cytokine Secretion by the Human Gingival Fibroblast Cell Line and Their Potential Link to Alzheimer’s Disease

The Immunomodulatory Effects of Apigenin and Quercetin on Cytokine Secretion by the Human Gingival Fibroblast Cell Line and Their Potential Link to Alzheimer’s Disease

<b>Background:</b> The link between periodontal pathogens, inflammation, and neurodegenerative processes, including Alzheimer’s disease (AD), is evident. <i>Porphyromonas gingivalis</i> and <i>Treponema denticola</i> release lipopolysaccharide (LPS), constituting...

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Main Authors: Anna Kurek-Górecka, Małgorzata Kłósek, Radosław Balwierz, Grażyna Pietsz, Zenon P. Czuba
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Pharmaceuticals
Subjects:
neurodegenerative disease
cytokines
apigenin
quercetin
periodontitis
Online Access:https://www.mdpi.com/1424-8247/18/5/628
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