A circuit for secretion‐coupled cellular autonomy in multicellular eukaryotic cells

A circuit for secretion‐coupled cellular autonomy in multicellular eukaryotic cells

Abstract Cancers represent complex autonomous systems, displaying self‐sufficiency in growth signaling. Autonomous growth is fueled by a cancer cell's ability to “secrete‐and‐sense” growth factors (GFs): a poorly understood phenomenon. Using an integrated computational and experimental approach...

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Main Authors: Lingxia Qiao, Saptarshi Sinha, Amer Ali Abd El‐Hafeez, I‐Chung Lo, Krishna K Midde, Tony Ngo, Nicolas Aznar, Inmaculada Lopez‐Sanchez, Vijay Gupta, Marilyn G Farquhar, Padmini Rangamani, Pradipta Ghosh
Format: Article
Language:English
Published: Springer Nature 2023-03-01
Series:Molecular Systems Biology
Subjects:
cellular autonomy
dose–response alignment (DoRA)
epidermal growth factor receptor (EGFR)
G proteins
Golgi secretion
Online Access:https://doi.org/10.15252/msb.202211127
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https://doi.org/10.15252/msb.202211127

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