Tumor-associated myeloid cells support murine T-ALL in the central nervous system via integrin signaling

Tumor-associated myeloid cells support murine T-ALL in the central nervous system via integrin signaling

Abstract: T-cell acute lymphoblastic leukemia (T-ALL) is a common pediatric malignancy, and central nervous system (CNS) involvement is associated with inferior prognoses. Here, we show that in the LIM-domain-only-2 transgenic and LN3 mouse models of T-ALL, leukemia blasts infiltrate the CNS, where...

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Bibliographic Details
Main Authors: Ryan S. Humphrey, Seohee Nam, Dennis C. Wylie, Lauren I. R. Ehrlich
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Blood Neoplasia
Online Access:http://www.sciencedirect.com/science/article/pii/S2950328025000305
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