DNA Sensor ABCF1 Phase Separates With cccDNA to Inhibit Hepatitis B Virus Replication

DNA Sensor ABCF1 Phase Separates With cccDNA to Inhibit Hepatitis B Virus Replication

Abstract Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) contributes to viral persistence and recurrence, however, how the host innate immune system responds to cccDNA is still less known. Here, based on cccDNA‐hepatic proteins interaction profiling, DNA sensor ATP‐binding cassette s...

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Main Authors: Caiyue Ren, Zhaoying Zhang, Yutong Dou, Yang Sun, Zhendong Fu, Liyuan Wang, Kai Wang, Chengjiang Gao, Yuchen Fan, Shuguo Sun, Xuetian Yue, Chunyang Li, Lifen Gao, Xiaohong Liang, Chunhong Ma, Zhuanchang Wu
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Advanced Science
Subjects:
ABCF1
cccDNA
HBV
HBx
phase separation
transcriptional machinery
Online Access:https://doi.org/10.1002/advs.202409485
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https://doi.org/10.1002/advs.202409485

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