TNBC response to paclitaxel phenocopies interferon response which reveals cell cycle-associated resistance mechanisms

TNBC response to paclitaxel phenocopies interferon response which reveals cell cycle-associated resistance mechanisms

Abstract Paclitaxel is a standard of care neoadjuvant therapy for patients with triple negative breast cancer (TNBC); however, it shows limited benefit for locally advanced or metastatic disease. Here we used a coordinated experimental-computational approach to explore the influence of paclitaxel on...

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Bibliographic Details
Main Authors: Nicholas L. Calistri, Tiera A. Liby, Zhi Hu, Hongmei Zhang, Mark A. Dane, Sean M. Gross, Laura M. Heiser
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Triple negative breast cancer (TNBC)
Single-cell RNA sequencing (scRNA-seq)
Transcription factor
Cell cycle
Interferon response
Live-cell imaging
Online Access:https://doi.org/10.1038/s41598-024-82218-9
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https://doi.org/10.1038/s41598-024-82218-9

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