Decoding chromosomal instability insights in CRC by integrating omics and patient-derived organoids

Decoding chromosomal instability insights in CRC by integrating omics and patient-derived organoids

Abstract Background Chromosomal instability (CIN) is involved in about 70% of colorectal cancers (CRCs) and is associated with poor prognosis and drug resistance. From a clinical perspective, a better knowledge of these tumour’s biology will help to guide therapeutic strategies more effectively. Met...

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Main Authors: Federica Papaccio, Manuel Cabeza-Segura, Blanca García-Micó, Francisco Gimeno-Valiente, Sheila Zúñiga-Trejos, Valentina Gambardella, María Fernanda Gutiérrez‐Bravo, Carolina Martinez‐Ciarpaglini, Pilar Rentero‐Garrido, Tania Fleitas, Susana Roselló, Juan Antonio Carbonell-Asins, Marisol Huerta, David Moro-Valdezate, Desamparados Roda, Noelia Tarazona, Manuel M. Sánchez del Pino, Andrés Cervantes, Josefa Castillo
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Chromosomal instability
Colorectal cancer
Multi-omics
Mass spectrometry-based proteomics
Patient-derived organoids
Online Access:https://doi.org/10.1186/s13046-025-03308-8
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https://doi.org/10.1186/s13046-025-03308-8

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