Adaptive randomised controlled non-inferiority multicentre trial (the Ketodex Trial) on intranasal dexmedetomidine plus ketamine for procedural sedation in children: study protocol

Adaptive randomised controlled non-inferiority multicentre trial (the Ketodex Trial) on intranasal dexmedetomidine plus ketamine for procedural sedation in children: study protocol

Introduction Up to 40% of orthopaedic injuries in children require a closed reduction, almost always necessitating procedural sedation. Intravenous ketamine is the most commonly used sedative agent. However, intravenous insertion is painful and can be technically difficult in children. We hypothesis...

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Main Authors: Martin Offringa, Samina Ali, Naveen Poonai, Serena Hickes, Petros Pechlivanoglou, Quynh Doan, Darcy Beer, Terry Klassen, Maryna Yaskina, Anna Heath, Scott Sawyer, Maala Bhatt, Vikram Sabhaney, Kamary Coriolano, April Kam
Format: Article
Language:English
Published: BMJ Publishing Group 2020-12-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/10/12/e041319.full
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https://bmjopen.bmj.com/content/10/12/e041319.full

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