VapC toxins promote the pathogenesis of Rickettsia heilongjiangensis by cleaving essential RNAs from both Rickettsia and its host.

Toxin-antitoxin (TA) modules enable bacteria to persist under stressful environments. However, they are typically absent from host-associated prokaryotes due to their potential host toxicity. Here, the obligate intracellular bacterium spotted fever group (SFG) rickettsiae, which causes mild to sever...

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Bibliographic Details
Main Authors: Yan Liu, Weiting Zhou, Jiaying Zhao, Qingyin Shi, Yu Xin, Xuan Ouyang, Yonghui Yu, Jun Jiao, Maozhang He, Yajun Song, Kehan Xu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-07-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1013380
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