The biological activity and potential of probiotics-derived extracellular vesicles as postbiotics in modulating microbiota-host communication
Abstract Probiotics such as Lactobacillus and Bifidobacterium spp. have been shown to be critical for maintaining host homeostasis. In recent years, key compounds of postbiotics derived from probiotic metabolism and cellular secretion have been identified for their role in maintaining organ immunity...
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| Format: | Article |
| Language: | English |
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BMC
2025-05-01
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| Series: | Journal of Nanobiotechnology |
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| Online Access: | https://doi.org/10.1186/s12951-025-03435-6 |
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| author | Xiaoming Zhang Ye Wang Qiyu E Muhammad Naveed Xiuli Wang Yinhui Liu Ming Li |
| author_facet | Xiaoming Zhang Ye Wang Qiyu E Muhammad Naveed Xiuli Wang Yinhui Liu Ming Li |
| author_sort | Xiaoming Zhang |
| collection | DOAJ |
| description | Abstract Probiotics such as Lactobacillus and Bifidobacterium spp. have been shown to be critical for maintaining host homeostasis. In recent years, key compounds of postbiotics derived from probiotic metabolism and cellular secretion have been identified for their role in maintaining organ immunity and regulating intestinal inflammation. In particular, probiotic-derived extracellular vesicles (PEVs) can act as postbiotics, maintaining almost the same functional activity as probiotics. They also have strong biocompatibility and loading capacity to carry exogenous or parental active molecules to reach distal organs to play their roles. This provides a new direction for understanding the intrinsic microbiota-host communication mechanism. However, most current studies on PEVs are limited to their functional effects/benefits, and their specific physicochemical properties, composition, intrinsic mechanisms for maintaining host homeostasis, and possible threats remain to be explored. Here, we review and summarize the unique physicochemical properties of PEVs and their bioactivities and mechanisms in mediating microbiota-host communication, and elucidate the limitations of the current research on PEVs and their potential application as postbiotics. |
| format | Article |
| id | doaj-art-fa0cb219ccfd435ca0514aaeb2d8f59f |
| institution | OA Journals |
| issn | 1477-3155 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj-art-fa0cb219ccfd435ca0514aaeb2d8f59f2025-08-20T01:51:34ZengBMCJournal of Nanobiotechnology1477-31552025-05-0123112110.1186/s12951-025-03435-6The biological activity and potential of probiotics-derived extracellular vesicles as postbiotics in modulating microbiota-host communicationXiaoming Zhang0Ye Wang1Qiyu E2Muhammad Naveed3Xiuli Wang4Yinhui Liu5Ming Li6College of Basic Medical Science, Dalian Medical UniversityCollege of Basic Medical Science, Dalian Medical UniversityCollege of Basic Medical Science, Dalian Medical UniversityCollege of Basic Medical Science, Dalian Medical UniversityCollege of Basic Medical Science, Dalian Medical UniversityCollege of Basic Medical Science, Dalian Medical UniversityCollege of Basic Medical Science, Dalian Medical UniversityAbstract Probiotics such as Lactobacillus and Bifidobacterium spp. have been shown to be critical for maintaining host homeostasis. In recent years, key compounds of postbiotics derived from probiotic metabolism and cellular secretion have been identified for their role in maintaining organ immunity and regulating intestinal inflammation. In particular, probiotic-derived extracellular vesicles (PEVs) can act as postbiotics, maintaining almost the same functional activity as probiotics. They also have strong biocompatibility and loading capacity to carry exogenous or parental active molecules to reach distal organs to play their roles. This provides a new direction for understanding the intrinsic microbiota-host communication mechanism. However, most current studies on PEVs are limited to their functional effects/benefits, and their specific physicochemical properties, composition, intrinsic mechanisms for maintaining host homeostasis, and possible threats remain to be explored. Here, we review and summarize the unique physicochemical properties of PEVs and their bioactivities and mechanisms in mediating microbiota-host communication, and elucidate the limitations of the current research on PEVs and their potential application as postbiotics.https://doi.org/10.1186/s12951-025-03435-6Probiotic-derived extracellular vesicles (PEVs)Extracellular vesicles (EVs)PostbioticsHost homeostasisMicrobiota-host communication |
| spellingShingle | Xiaoming Zhang Ye Wang Qiyu E Muhammad Naveed Xiuli Wang Yinhui Liu Ming Li The biological activity and potential of probiotics-derived extracellular vesicles as postbiotics in modulating microbiota-host communication Journal of Nanobiotechnology Probiotic-derived extracellular vesicles (PEVs) Extracellular vesicles (EVs) Postbiotics Host homeostasis Microbiota-host communication |
| title | The biological activity and potential of probiotics-derived extracellular vesicles as postbiotics in modulating microbiota-host communication |
| title_full | The biological activity and potential of probiotics-derived extracellular vesicles as postbiotics in modulating microbiota-host communication |
| title_fullStr | The biological activity and potential of probiotics-derived extracellular vesicles as postbiotics in modulating microbiota-host communication |
| title_full_unstemmed | The biological activity and potential of probiotics-derived extracellular vesicles as postbiotics in modulating microbiota-host communication |
| title_short | The biological activity and potential of probiotics-derived extracellular vesicles as postbiotics in modulating microbiota-host communication |
| title_sort | biological activity and potential of probiotics derived extracellular vesicles as postbiotics in modulating microbiota host communication |
| topic | Probiotic-derived extracellular vesicles (PEVs) Extracellular vesicles (EVs) Postbiotics Host homeostasis Microbiota-host communication |
| url | https://doi.org/10.1186/s12951-025-03435-6 |
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