Toward a high-throughput in vitro model for estimating vitreous humor permeability of topically applied drugs

Toward a high-throughput in vitro model for estimating vitreous humor permeability of topically applied drugs

Abstract The vitreous humor of the eye presents a crucial target for posterior segment therapy due to its proximity to the retina and relatively easy accessibility. Although intravitreous injections have long been the primary method for treating posterior segment disorders, recent successes in non-i...

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Main Authors: Anna Vincze, Eszter Simon, Gábor Koplányi, József Gergely Stankovits, Diána Balogh-Weiser, Benjámin Gyarmati, Zoltán Zsolt Nagy, György T. Balogh
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Posterior segment of the eye
Ocular permeability
In vitro permeability model
PAMPA
Vitreous humor
Vitreous substitutes
Online Access:https://doi.org/10.1038/s41598-025-93425-3
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https://doi.org/10.1038/s41598-025-93425-3

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