Gradual changes within long-lived influenza virus-specific CD8+ T cells are associated with the loss of public TCR clonotypes in older adultsResearch in context

Gradual changes within long-lived influenza virus-specific CD8+ T cells are associated with the loss of public TCR clonotypes in older adultsResearch in context

Summary: Background: Susceptibility to life-threatening influenza increases with age, partly due to declining immunity. Frequency, phenotype and T-cell receptor (TCR) composition of influenza-specific CD8+ T-cells directed at the prominent A2/M158 influenza epitope change across the human lifespan....

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Bibliographic Details
Main Authors: Carolien E. van de Sandt, Hayley A. McQuilten, Malet Aban, Thi H.O. Nguyen, Sophie A. Valkenburg, Emma J. Grant, Sneha Sant, Jamie Rossjohn, Stephanie Gras, Jane Crowe, Katherine Kedzierska
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:EBioMedicine
Subjects:
Longevity
Epitope-specific CD8+ T cells
TCR
Adults
Elderly
Influenza
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396425001410
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http://www.sciencedirect.com/science/article/pii/S2352396425001410

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