Ailanthone blocks mitophagy to promote mtDNA leakage through BAX-BAK1 pores and suppress hepatocellular carcinoma cell proliferation

Ailanthone blocks mitophagy to promote mtDNA leakage through BAX-BAK1 pores and suppress hepatocellular carcinoma cell proliferation

IntroductionHepatocellular carcinoma (HCC), the third leading cancer mortality worldwide, shows rising incidence. The mitochondria in HCC cells are prone to damage from metabolic stress and oxidative stress, necessitating heightened mitophagy for mitochondrial homeostasis and cell survival. Thus, mi...

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Bibliographic Details
Main Authors: Yan Qin, Ying Gao, Dan Wu, Qing-Qing Liu, Chang Su, Guan Liu, Le Yang, Ming-Gao Zhao, Jing-Yue Yao
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Pharmacology
Subjects:
hepatocellular carcinoma
ailanthone
PINK1-PRKN
mtDNA
BAX-BAK1
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1509482/full
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https://www.frontiersin.org/articles/10.3389/fphar.2024.1509482/full

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