Curcumin inhibits IFN-γ induced PD-L1 expression via reduction of STAT1 Phosphorylation in A549 non-small cell lung cancer cells

Curcumin inhibits IFN-γ induced PD-L1 expression via reduction of STAT1 Phosphorylation in A549 non-small cell lung cancer cells

Abstract Background Immune evasion in non-small cell lung cancer (NSCLC) is largely mediated by programmed death-ligand 1 (PD-L1), which is upregulated by interferon-gamma (IFN-γ)-induced STAT1 activation. Targeting this pathway may improve immunotherapy outcomes. Curcumin, a natural polyphenol, has...

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Bibliographic Details
Main Authors: Dian Jamel Salih, Saraa Hanna Barsoom, Ghazwan Fawzi Ahmed, Shler Qasim Hussien, Qais Al Ismaeel, Asaad A. B. Alasady, Tahseen A. Alsalim, Ahmed Mohammed Salih
Format: Article
Language:English
Published: Springer 2025-06-01
Series:Saudi Pharmaceutical Journal
Subjects:
Lung cancer
Curcumin
STAT1
PD-L1
IFN-γ
Online Access:https://doi.org/10.1007/s44446-025-00018-2
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https://doi.org/10.1007/s44446-025-00018-2

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