Phosphine Oxide Indenoquinoline Derivatives: Synthesis and Biological Evaluation as Topoisomerase I Inhibitors and Antiproliferative Agents

Phosphine Oxide Indenoquinoline Derivatives: Synthesis and Biological Evaluation as Topoisomerase I Inhibitors and Antiproliferative Agents

The synthesis of phosphorous indenoquinolines and their biological evaluation as topoisomerase 1 (TOP1) inhibitors and antiproliferative agents were performed. First, the preparation of new hybrid 5<i>H</i>-indeno[2,1-<i>c</i>]quinolines with a phosphine oxide group was perfo...

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Bibliographic Details
Main Authors: Alba Rodriguez-Paniagua, Cinzia Tesauro, Birgitta R. Knudsen, Maria Fuertes, Concepción Alonso
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Molecules
Subjects:
indenoquinolines
phosphine oxide
topoisomerase I
enzyme inhibition
antiproliferative agents
Online Access:https://www.mdpi.com/1420-3049/29/24/5992
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