Integrative metabolomics and genomics reveal molecular signatures for type 2 diabetes and its cardiovascular complications

Integrative metabolomics and genomics reveal molecular signatures for type 2 diabetes and its cardiovascular complications

Abstract Background Metabolites are pivotal in the biological process underlying type 2 diabetes (T2D) and its cardiovascular complications. Nevertheless, their contributions to these diseases have not been comprehensively evaluated, particularly in East Asian ancestry. This study aims to elucidate...

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Main Authors: Chunxiao Cheng, Yuanjiao Liu, Lingyun Sun, Jiayao Fan, Xiaohui Sun, Ju-Sheng Zheng, Lin Zheng, Yimin Zhu, Dan Zhou
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Cardiovascular Diabetology
Subjects:
Metabolome
Type 2 diabetes
Cardiometabolic diseases
East Asians
Mendelian randomization
Genetic association studies
Online Access:https://doi.org/10.1186/s12933-025-02718-4
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https://doi.org/10.1186/s12933-025-02718-4

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